L-Methionine: If you have a genetic issue making methionine, this one's for you. Try taking at least 1,000 mg per day, NOW Foods, LINK
I suggest that we could refurbish Peter Thiel’s slogan and similarly say " we wanted a cure for cancer but instead we got... more cancer". Not quite as catchy as flying cars, I know, but a true story.
Editorial Sources and Fact-Checking
Concerns about hormone replacement therapy (HRT) began in the early 2000s, when the Women’s Health Initiative (WHI) study reported a link between combined estrogen and progestin and an increased risk of breast cancer and cardiovascular disease. The study also stated that hormone therapy caused more harm than good in postmenopausal women, showing that estrogen alone appeared to be related to an increased risk of stroke and was not beneficial for coronary artery disease. ( 4) Treating menopausal symptoms can often be challenging, as the symptoms tend to vary on an individual basis. Many women experience only local or systemic symptoms, while some experience a combination of both. The cause of menopause is typically the same for many women, regardless of whether the symptoms are local or systemic. Women, specifically those experiencing signs of urogenital atrophy, also tend to feel embarrassed to report these symptoms or think that the local or topical therapy will carry the same risk as does the systemic treatment of menopausal symptoms, known as menopausal hormone therapy (MHT). Around 50% of women will experience symptoms of urogenital atrophy, which include vaginal dryness, itching, infections of the urinary tract, urinary incontinence, and dyspareunia. Unfortunately, only 25% of them will seek options for treatment and avoid treatment altogether.  Then, two years later, the estrogen-only study was also stopped ahead of time, because it also uncovered an increased risk of blood clots. For these women, though, there was no significant increase in breast cancer risk. ( 6)
Ashwagandha / Withanolides: This is a tough one. According to the 3rd party testing done by ConsumerLabs, the majority of ashwagandha supplements don't contain enough withanolides to be clinically relevant. Furthermore, about 50% of supplement companies are making dishonest claims regarding withanolide content. Withanolide is the active ingredient in ashwagandha and clinical studies that find benefits from ashwagandha usually use at least 10 mg of withanolide per day. Nature's Way has by far the most withanolides (90 mg per capsule despite claiming to "only" have 20 mg) but Nature's Way is not organic. Organic ashwaganda is important to me because studies have shown major amounts of pesticides and herbicides in ashwagandha supplements, including a hefty blast of atrazine ( ref) which acts like estrogen in our body. Anyway, Organic India Ashwagandha ranks best overall in my estimation but you'll need to take 4 pills per day, instead of the recommended 2, if you want the full clinical potential. Start with a fairly low dose (e.g. 1 pill) because some people get itches and rashes from withanolides - mostly people with the BCHE gene issue that are sensitive to nightshade plants. Here is the Organic India Ashwagandha LINK
Besides a few of my past college adventures, fish play a central role in this book. They breathe in and soak in estrogenics day and night. We’ll discuss the unfortunate estrogenic burdens within fat, livers, and urine in animals ranging from polar bears to alligators, as well as the resulting health problems from all these exposures, but fish will be featured more consistently and more prominently than the rest. Fish are second only to humans in this book. We can learn a lot from the humble and tasty fish. Recent insights into infertility from artificial estrogens, for example, were first discovered in fish. I hesitate to include supplements here because there is no "one-size-fits-all" supplement plan. Your DNA, sex, age, health history, current diet, personal goals, and your body's responses all determine what supplements you should utilize. That’s one reason I do DNA consultingand believe it's incredibly empowering.
In addition, another study’s findings indicate that the timing of when HRT is first administered in relation to when a patient goes through menopause may be important. That 2013 study found that when HRT was started more than 10 years after menopause (or when the patient was 60 or older) there was a reduction in coronary heart disease events and total mortality.Vitamin C: I use Spring Valley, 1,000 mg, with Rose Hips, from Walmart. Cheap and vitamin C has no major quality issues. Make sure there is no sugar in your vitamin C supplements! If you need higher doses, I recommend adding Bulk Supplement vitamin C powder to a shake, smoothie, or some similar drink, LINK
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